Reduced spectrin-ankyrin binding in a South African hereditary elliptocytosis kindred homozygous for spectrin St Claude.

percentage of senescent cells in the dense fraction than do Percoll gradients. In summary, these results confirm that the #1% most dense RBC from dogs represent a predominantly aged population of cells. Labeling a cohort of young cells further enhances the enrichment for old RBC in this fraction. To the extent that canine RBC serve as an accurate model for human RBC, it can be concluded that the changes that occur late in the human RBC life span and trigger RBC removal can be studied by fractionating the cells on arabinogalactan density gradients.